Scientists at Washington University have created a compound called SLU-PP-332 that activates specific proteins usually engaged by exercise. Experiments in rodent cells have been successful, suggesting potential human applications that could improve fitness and reduce the risk of age- or obesity-related conditions such as diabetes and heart failure. The theory is that a drug replicating exercise effects could prevent muscle atrophy, slow down or prevent cancers, and other ailments. However, experts caution that it should not replace physical activity. "We cannot replace exercise; exercise is important on all levels," said Bahaa Elgendy, the project's principal investigator. "If I can exercise, I should get the physical activity. But there are cases where a substitute is needed."

 

The SLU-PP-332 "Fitness Pill" Resists Muscle Fatigue

Presented at the spring meeting of the American Chemical Society (ACS), SLU-PP-332 activates specialized proteins known as estrogen-related receptors (ERRs). After a decade of work, the compound was developed to activate all three forms of ERR, including ERRα, which regulates exercise-induced body adaptations and other important physiological processes in muscles. In experiments with mice, SLU-PP-332 increased a fatigue-resistant type of muscle fiber without exercise and improved the animals' endurance. While still in early stages, if successfully translated to humans, SLU-PP-332 could benefit those unable to exercise due to physical challenges and potentially create a buzz in the supplement world.