P7C3-A20 compound has neuroprotective effects, promotes hippocampal neurogenesis, and improves functional outcomes after experimental trauma.

 

P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an  antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury  treatment

 

 

Traumatic brain injury (TBI) poses a serious threat to the health of both humans and animals. TBI is mainly caused by mechanical external forces, and the main causes include fighting, impact, falling, etc. TBI reduces the quality of life of patients and may even lead to severe disability or death

 

P7C3-aA20 is a derivative of P7C3, which can penetrate the blood-brain barrier, stabilize cellular energy levels, and has the potential to treat TBI. A study has demonstrated that P7C3-A20 has a neuroprotective effect on ischemic stroke [6]. It also exerts a protective effect on the hippocampal neurons of primates [7]. Although P7C3-A20 has been confirmed to exert neuroprotective effects in various diseases such as ischemic stroke and neurodegenerative diseases, it remains unclear whether P7C3-A20 can have therapeutic effects on TBI in rats by regulating autophagy and apoptosis, as well as its possible molecular mechanisms.

 

In the experiment, rats treated with P7C3-A20 after TBI showed recovery in motor function and learning and memory ability. These results indicate that P7C3-A20 can treat the motor and memory functions of rats after TBI. P7C3-A20 exerts a neuroprotective effect on the brain by inhibiting the excessive autophagy and apoptotic responses in rats after TBI.