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| Physical Characters and Index |
Product Name:7,8-Dihydroxyflavone
Other name:7,8-DHF
CAS:38183-03-8
Molecular Formula:C15H10O4
Molecular Weight:254.24
Purity:99%
Appearance:Yellow or tan powder.
Melting point:243-246°C
Boiling point:494.4±45.0 °C(Predicted)
Storage conditions:Inert atmosphere,Room Temperature |
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| Use and description |
7,8-DHF mimics the effects of brain-derived neurotrophic factor (BDNF) in the brain by activating the tropomyosin-related kinase B (TrkB) receptors .The therapeutic potential of BDNF is restricted due to its short half-life (less than 10 minutes) and its inability to cross the blood-brain barrier because of its large size. Unlike BDNF 7,8-DHF is able to penetrate the blood-brain barrier and enter the central nervous system (CNS) .
7,8-DHF also increases the production of Nrf2. Nrf2 increases antioxidants enzymes such as heme oxygenase 1 (HO-1) and also enzymes that repair DNA (8-oxoguanine DNA glycosylase-1 - OGG1) |
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