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| Physical Characters and Index |
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| Use and description |
| CN-105, a 5 amino acid peptide derived from the receptor binding face of the apoE receptor binding region. This second generation apoE mimetic is associated with increased potency and CNS penetration27 and improves outcome in several acute CNS pathologies that contribute to secondary cerebral injury following SAH, including ischaemia,28 mechanical brain injury29 and intraparenchymal haemorrhage.27 Moreover, CN-105 has recently been translated to phase I clinical trials, where it was demonstrated to be safe, well tolerated and possessed favourable pharmacokinetics.30 We now test the hypothesis that systemic administration of CN-105 will reduce the vasculopathy and functional deficits associated with a validated preclinical model of aneurysmal SAH |
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