| |
| Physical Characters and Index |
English name: L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)
CAS number: 99141-91-0
Molecular formula: C11H20N2O4
Molecular weight: 244.29 |
| |
| Use and description |
| ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), reduces extracellular 5-HT concentration and downregulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 readily crosses the blood-brain barrier. |
|
